Diffusionweighted imaging dwi and the apparent diffusion. Hepatic primary solitary extramedullary plasmacytoma emp is a rare disease with few cases reported in the literature. Bcl2 expression is associated with poor prognosis of. Extramedullary plasmacytoma is a plasma cell tumor that grows. Sp is a highly radiosensitive tumor and most patients undergo radiation therapy as the first line of treatment, resulting in an excellent local control rate.
Additional information is now available on the role of serum free light chains and pet scanning. Solitary plasmacytomas are uncommon plasma cell disorders, which may present as a single bone lesion pbone or extramedullary plasmacytoma pem. A plasmacytoma is a discrete, solitary mass of neoplastic monoclonal plasma cells in either bone or soft tissue extramedullary. For spb and extramedullary plasmacytoma the distinction is the presence of only one lesion either in bone or soft tissue.
Solitary plasmacytoma sp is the clinical condition characterized by the localized proliferation of clonal plasma cells. These tumors may be described as localized or diffuse in. Solitary plasmacytoma multiple myeloma texas oncology. Bcl2 expression is associated with poor prognosis of solitary plasmacytoma of bone article in annals of hematology 933 september 20 with 12 reads how we measure reads. This study reports a case of an extramedullary plasmacytoma of the. Since the previous guideline several new articles on prognostic factors, treatment and outcome in patients with solitary plasmacytoma of bone have been published. The prognosis and treatment of solitary plasmacytomas is very. Radiation therapy is the commonly used treatment for both the types of solitary plasmacytoma, as solitary plasmacytomas are localized and there is only one tumor present. Diagnosis, treatment, and response assessment in solitary. Solitary plasmacytoma of bone spb, also called osseous plasmacytoma is a localized tumor in the bone comprised of a single clone of plasma cells in the absence of other features of mm ie, anemia, hypercalcemia, renal insufficiency, or multiple lytic bone lesions. In contrast, sep is nearly always truly localized and has a high cure rate with local treatment. Treatment approaches and outcomes in plasmacytomas. What is the risk of recurrence of solitary plasmacytoma.
Radiation therapy for the solitary plasmacytoma journalagent. Diagnosis and management of solitary plasmacytoma of bone. The diagnosis and management of patients with solitary plasmacytoma requires the same range of clinical and laboratory expertise as for patients with mm uk myeloma forum, 2001. Multiple myeloma is a type of blood cancer of the plasma cells which are found in the bone marrow. Now customize the name of a clipboard to store your clips. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Pdf solitary bone plasmacytomas are part of a wide range of monoclonal neoplasms that share a common progenitor in the b lymphocyte lineage. The primary treatment for most patients will be radiotherapy, but. Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue. Solitary plasmacytomas represent approximately 5% of all patients with myeloma. The workup of a patient thought to have multiple myeloma may reveal a solitary plasmacytoma. Case report a primary extramedullary plasmacytoma of the tongue. The definition of sp has been evolving as a result of improvement in imaging technology as well as the availability of more sensitive techniques that can detect small populations of clonal plasma cells in the bone marrow. Local radiotherapy is the treatment of choice for solitary bone plasmacytome sbp.
Radiation therapy for treating solitary plasmacytoma. A solitary plasmacytoma is a single cancer site that may involve the bone osseous or other tissues extraosseous or extramedullary. Guidelines on the diagnosis and management of solitary. The plasma cell neoplasms may present in soft tissue as extramedullary plasmacytoma emp, in bone as a solitary plasmacytoma of bone spb.
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